Italian residents who have registered an Italian Exchange account can access the Betfair Exchange API. Italian residents can register an account via https://register.betfair.it/account/italy/registration
To use the Italian Exchange with API-NG you need to create an Application Key for your Italian Exchange account by following the process outlined via https://api.developer.betfair.com/services/webapps/docs/display/1smk3cen4v3lu3yomq5qye0ni/Application+Keys
Once you have done created an App Key, you will need to login to API-NG using the Italian Exchange endpoint which is as follows:
To use the interactive login with the Italian Exchange your App Key will need to be white-listed by Betfair. White-listing is not required to use the non-interactive login method.
There are several additional regulatory rules which apply specifically and only to accounts betting on the Italian Exchange (https://www.betfair.it/exchange):
The Italian Exchange isn't available for betting between 0100 and 0500 GMT